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THE MALLARINO LAB AT PRINCETON UNIVERSITY |
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The lab is broadly interested in addressing two questions: (1) what are the genetic and developmental mechanisms by which form and function are generated during vertebrate development? and (2) how are these processes modified during evolutionary time to produce the spectacular phenotypic diversity seen in nature?
We combine the study of emerging model organisms, because of their diverse, naturally occurring and ecologically relevant phenotypes, with traditional model species, because of the powerful molecular and genetic tools available, to explore questions relating to patterning and the evolution of novelty in the mammalian skin. The mammalian skin is a powerful model because it exhibits remarkable diversity in structure and function across species, is experimentally accessible/tractable, and the molecular mechanisms underlying its formation are well characterized. We use a variety of approaches, including experimental embryology, transcriptomic and epigenomic profiling, comparative genomics, functional genetics, and imaging, to uncover gene function and understand mechanisms of evolutionary change. |
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